Avoid or Use Alternate Drug. Generic name: IRON SUCROSE 20mg in 1mL HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication. Pasricha SR, Flecknoe-Brown SC, Allen KJ, Gibson PR, McMahon LP, Olynyk JK, Roger SD, Savoia HF, Tampi R, Thomson AR, Wood EM, Robinson KL. iron sucrose increases levels of calcium citrate by enhancing GI absorption. Parenteral iron dextran therapy. 3. Applies only to oral form of both agents. Serious hypersensitivity reactions, including anaphylactic-type reactions, some of which have been life-threatening and fatal, have been reported in patients receiving Venofer. If we don't have the calculator you need we'll try to make it for you and add it to the website. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. iron sucrose decreases levels of manganese by inhibition of GI absorption. If we don't have the calculator you need then tell us the details and we'll make it for you. didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. If you have private insurance, Venofer or Monoferric may be on the list of covered medications. Venofer [package insert]. It varies from increases in dietary intake of iron (usually for prophylaxis purposes) to oral, intramuscular or intravenous therapy. 2) Koch TA, Myers J, Goodnough LT. (2015) Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. Minor/Significance Unknown. deferasirox decreases levels of iron sucrose by inhibition of GI absorption. Avoid or Use Alternate Drug. Applies only to oral form of both agents. Avoid or Use Alternate Drug. Intravenous therapy is preferred for urgent intervention and when oral iron cannot be absorbed or the patient suffers from chronic renal impairment. Copyright 2014 - 2023 The Calculator .CO |All Rights Reserved|Terms and Conditions of Use, Parenteral Iron Replacement For Iron Deficiency Anemia Calculator, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Clinical use of the total dose intravenous infusion of iron dextran, When is high-dose intravenous iron repletion needed? If these effects continue or worsen, tell your doctor.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. 2010;18(3). 20 mg/mL for Iron sucrose; 5 mg/mL for Ferric gluconate. Baloxavir may bind to polyvalent cations resulting in decreased absorption. Most Your doctor will do laboratory tests to monitor your response. A healthcare provider will give you this injection. Hollands J, Foote E, Rodriguez A. These adverse reactions have occurred up to 30 minutes after the administration of Venofer injection. Intravenous iron replacement can take place as total dose (as in the case of iron-dextran or iron carboxymaltose) or as split dose (in the case of iron sucrose). Modify Therapy/Monitor Closely. Properly discard this product when it is expired or no longer needed. Applies only to oral form of both agents. In a randomized, open-label, dose-ranging trial for iron maintenance treatment with Venofer in pediatric patients with CKD on stable erythropoietin therapy [see Clinical Studies ( 14.7)], at least one adverse reaction was experienced by 57% (27/47) of the patients receiving Venofer 0.5 mg/kg, 53% (25/47) of the patients receiving Venofer 1 mg . https://www.uptodate.com/ (Requires subscription). Next Steps Evidence Creator Insights Dr. Andreas M. Ganzoni About the Creator Applies only to oral form of both agents. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Minor/Significance Unknown.iron sucrose increases levels of calcium chloride by enhancing GI absorption. Applies only to oral form of both agents. Applies only to oral form of both agents. Minor/Significance Unknown. March 2, 2015 [IRON SUCROSE REQUIREMENT CALCULATION FOR SEVERE ANEMIA] DPMU Anantapuramu | National Health Mission 1 Formula for calculating the required dose of Iron sucrose 2.4 X Pre-pregnancy Weight in Kgs X Hb% deficit{11-actual Hb%} in mgs Plus Iron required to replenish the iron stores = 500mg Prepregnancy Weight = 45 kgs . iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. Intravenous iron sucrose: establishing a safe dose. Monitor Closely (1)vitamin E decreases levels of iron sucrose by increasing hepatic clearance. Deferasirox chelates iron. Only administer Feraheme as an intravenous infusion over at least 15 minutes and only when personnel and therapies are immediately available for the treatment of anaphylaxis and other hypersensitivity reactions. iron sucrose increases levels of calcium chloride by enhancing GI absorption. Use Caution/Monitor. J Med. Separate dosing of tetracyclines from these products. 2010;18(3). 1970; 100(7):301-3. Accessed: 4/12/2011. Separate dosing of tetracyclines from these products. Iron deficit - equation derivation: Assumptions: -Blood volume = 65 mL/kg -Hemoglobin conc target =14.0 g/dL -Deficits in body stores are ignored. iron sucrose decreases levels of levofloxacin by inhibition of GI absorption. Applies only to oral form of both agents. Hemoglobin iron deficit = 60 x (14 - 8) x (2.145) = 772 mg iron. The iron deficit estimation is based on the Ganzoni formula: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores. Administer Venofer in 3 divided doses, given by slow intravenous infusion, within a 28 day period: 2 infusions each of 300 mg over 1.5 hours 14 days apart followed by one 400 mg infusion over 2.5 hours 14 days later. If dose exceeds 20mg/kg it should be rounded down to 20mg/kg OR administration of the total dose has to be split and given 7 days apart. rabeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. commonly, these are "non-preferred" brand drugs or specialty 1996 Aug;11(4):139-46. Serious - Use Alternative (1)iron sucrose decreases levels of tetracycline by inhibition of GI absorption. Kidney Int. Pain, swelling, or redness at the injection site may occur. Interaction only with oral iron administration. DOSAGE AND ADMINISTRATION: Oral iron should be discontinued prior to administration of INFeD. Minor/Significance Unknown. Applies only to oral form of both agents. In post-marketing safety studies of Venofer in 1,051 patients with HDD-CKD, adverse reactions reported by >1% were cardiac failure congestive, sepsis and dysgeusia. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Use Caution/Monitor. Calculates iron deficit for dosing iron. Iron deficiency anemia calculator (diagnosis), Iron deficiency anemia vs. Use Caution/Monitor. J Lab Clin Med; 111(5):566-70. Monitor Closely (1)lansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Administer Venofer only intravenously by slow injection or by infusion. Use Caution/Monitor. an automated flowchart approach. 0.5 mg/kg (not to exceed 100 mg/dose) diluted to a concentration of 1 to 2 mg/mL in 0.9% sodium chloride IV over 5 to 60 minutes Administer every 4 weeks for 12 weeks Do not dilute to concentrations below 1 mg/mL Comments: Treatment may be repeated if necessary. (1970) Intravenous iron-dextran: therapeutic and experimental possibilities. Total cumulative Venofer dose = number of 100mg ampoules for Hb increase. Applies only to oral form of both agents. Feraheme, when added to intravenous infusion bags containing either 0.9% Sodium Chloride Injection, USP (normal saline), or 5% Dextrose Injection, USP, at concentrations of 2-8 mg elemental iron per mL, should be used immediately but may be stored at controlled room temperature (25C 2C) for up to 4 hours or refrigerated (2-8 C) for up to 48 hours. Separate dosing of tetracyclines from these products. Minor (2)calcium chloride decreases levels of iron sucrose by inhibition of GI absorption. Administer Venofer early during the dialysis session (generally within the first hour). famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Parenteral iron dextran therapy: a review. Where: Medicine concentration Amount of active substance per a given volume of your drug. Dosing Considerations (8-10) Maximum single dose of iron sucrose in all other patients is 300 mg every week. Maximum infusion rate: 100 mg / hour (Slow infusion rate of iron sucrose is recommended to minimize adverse reactions, especially hypotension) Frequency of infusion: Dose may be repeated up to 3 times weekly to provide total iron dose. Monitor Closely (1)cimetidine will decrease the level or effect of iron sucrose by increasing gastric pH. Andreas M. Ganzoni, MD, is a physician and researcher in the internal medicine department at the University of Zurich in Zurich, Switzerland. Information last revised December 2022. Serious - Use Alternative (1)iron sucrose decreases levels of moxifloxacin by inhibition of GI absorption. Monitor Closely (1)pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Please note that once you have closed the PDF you need to click on the Calculate button before you try opening it again, otherwise the input and/or results may not appear in the pdf. Have resuscitation equipment and personnel trained in the detection and treatment of anaphylactic-type reactions readily available during INFeD administration. Applies only to oral form of both agents. IDA symptoms vary, may not be specific and include tiredness, weakness, shortness of breath. Drug: Comments: A: Acyclovir 1: Dose using a 40% adjusted body weight; Amikacin 2: Dose using a 40% adjusted body weight; Amphotericin B (liposomal) 3 Consider capping body weight to 100 kg; Atracurium 4: Dose using ideal body weight; The use of ideal body weight has been shown to be associated with a more predictable muscle strength recovery within 60 minutes and a lack of need for antagonism . Indications: Feraheme is indicated for the treatment of iron deficiency anemia (IDA) in adult patients: who have intolerance to oral iron or have had unsatisfactory response to oral iron or who have chronic kidney disease (CKD). Then enter the value of the Dosage and choose the unit of measurement from the drop-down menu. Adult Patients with Hemodialysis Dependent-Chronic Kidney Disease (HDD-CKD): Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session. Treatment of anemia due to iron deficiency. DOSAGE AND ADMINISTRATION: The recommended dose of Feraheme is an initial 510 mg dose followed by a second 510 mg dose 3 to 8 days later. It is usually given slowly over 2 to 5 minutes or as directed by your doctor. Applies only to oral form of both agents. Applies only to oral form of both agents. Use (s): Iron deficiency anemia in patients with chronic kidney disease (CKD) Minor/Significance Unknown. This information does not assure that this product is safe, effective, or appropriate for you. calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Iron Dextran Dosing Calculator (iron deficit). This document does not contain all possible drug interactions. 2 DOSAGE & ADMINISTRATION Venofer must only be administered intravenously either by slow injection or by infusion. Avoid or Use Alternate Drug. Iron deficiency can occur at any stage of life, due to physiological demands, for example, during pregnancy, childhood growth or prolonged periods of sickness. Applies only to oral form of both agents. This drug is available at a higher level co-pay. 10th ed. Applies only to oral form of both agents. Serious - Use Alternative (1)iron sucrose decreases levels of mycophenolate by inhibition of GI absorption. 2015: 763576. Dose administration to an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy. Applies only to oral form of both agents. 0.5 mg/kg/min (0.005 mL/kg/min) Maximum infusion rate (if tolerated) Increase to 8 mg/kg/min (0.08 mL/kg/min) Monitor the patient's vital signs throughout the infusion. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Applies only to oral form of both agents. Data from Ferrlecit postmarketing spontaneous reports indicate that individual doses exceeding 125 mg may be associated with a higher incidence and/or severity of adverse events. concentration of elemental iron (mg/ml) in the product being used: This calculator will help pinpoint potential causes of anemia based on an automated flowchart approach. Pediatric Patients (2 Years of Age and Older). dexlansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. The dosage of Venofer is expressed in mg of elemental iron. INDICATIONS AND USAGE: Intravenous or intramuscular injections of INFeD are indicated for treatment of patients with documented iron deficiency in whom oral administration is unsatisfactory or impossible. Separate by 2 hr. Manage and view all your plans together even plans in different states. Minor (1)iron sucrose, benazepril. Minor/Significance Unknown.iron sucrose increases levels of calcium carbonate by enhancing GI absorption. Contraindicated. Most studies have used IV iron sucrose (maximum dose of 200 mg per setting) or ferric carboxymaltose (maximum dose of 1000 mg per week). Venofer treatment may be repeated if iron deficiency reoccurs. All adult and pediatric patients receiving Venofer require periodic monitoring of hematologic and iron parameters (hemoglobin, hematocrit, serum ferritin and transferrin saturation). Applies only to oral form of both agents. Parenteral iron supplementation. Steps on how to print your input & results: 1. Feraheme does not contain antimicrobial preservatives. Brand name: Venofer Drug class: Iron Preparations Chemical name: iron saccharate CAS number: 8047-67-4 Medically reviewed by Drugs.com on Oct 25, 2022. Applies only to oral form of both agents. Taking the case of a patient weighing 75 kg (165.3 lbs) with a target hemoglobin value of 13 g/dL (130 g/L or 8.07 mmol/L), an actual hemoglobin of 9.5 g/dL (95 g/L or 5.9 mmol/L) and iron stores of 500 mg, the iron deficit is: Iron deficit = 75 x (13 9.5) x 2.4 + 500 = 1,130 mg. Iron Deficiency Anemia: Periodic hematologic determination (hemoglobin and hematocrit) is a simple and accurate technique for monitoring hematological response, and should be used as a guide in therapy. Serious - Use Alternative (1)iron sucrose decreases levels of minocycline by inhibition of GI absorption. Slowing the infusion rate may alleviate symptoms. It is usually given slowly over 2 to 5 minutes or as directed by your doctor. in the colostrum of 10 iron deficient breastfeeding women who were 2 to 3 days postpartum and received a single dose of 100 mg of intravenous iron . https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvdmVub2Zlci1pcm9uLXN1Y3Jvc2UtMzQyMTYy, View explanations for tiers and No additional iron to replenish stores. When administered via infusion, dilute up to 750 mg of iron in no more than 250 mL of sterile 0.9% sodium chloride injection, USP, such that the concentration of the infusion is not less than 2 mg of iron per mL and administer over at least 15 minutes. Immune system disorders: Anaphylactic-type reactions, angioedema, Nervous system disorders: Convulsions, collapse, light-headedness, loss-of-consciousness, Respiratory, thoracic and mediastinal disorders: Bronchospasm, dyspnea, Musculoskeletal and connective tissue disorders: Back pain, swelling of the joints, General disorders and administration site conditions: Hyperhidrosis, Published studies on intravenous iron sucrose treatment after first trimester of pregnancy not shown adverse maternal or fetal outcomes; available reports of intravenous iron sucrose use in pregnant women during first trimester are insufficient to assess risk of major birth defects and miscarriage; iron deficiency anemia during pregnancy should be treated because there are risks to mother and fetus associated with untreated iron deficiency anemia (IDA) in pregnancy; risks to fetus associated with maternal severe hypersensitivity reactions, Severe adverse reactions including circulatory failure (severe hypotension, shock including in the context of anaphylactic reaction) may occur in pregnant women with parenteral iron products which may cause fetal bradycardia, especially during second and third trimester, Iron sucrose is present in human milk, and available published reports following exposure to 100-300 mg intravenous iron sucrose have not reported adverse reactions in breastfed infants; there are no data on effects on milk production, Developmental and health benefits of breastfeeding should be considered, along with mothers clinical need for treatment and any potential adverse effects on breastfed child from therapy or from underlying maternal condition. iron sucrose increases levels of calcium carbonate by enhancing GI absorption. Use Caution/Monitor. Use Caution/Monitor. Hemoglobin can be input in g/dL, g/L or mmol/L and refers to the amount of hemoglobin in the red blood cells. Applies only to oral form of both agents. It is unlikely . Inspect parenteral drug products visually for the absence of particulate matter and discoloration prior to administration. The recommended dosage of iron sucrose for repletion of iron deficiency in patients undergoing hemodialysis is 5ml of iron sucrose (100mg of elemental iron) delivered intravenously during the dialysis session. Iron stores 500 mg for body weight greater than or equal to 35 kg (77 lbs) and 15 mg/kg for body weight less than 35 kg. Use Caution/Monitor. Creating an account is free and takes less than 1 minute. PRECAUTIONS: Before using iron sucrose, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. Minor/Significance Unknown. Adding plans allows you to compare formulary status to other drugs in the same class. Applies only to oral form of both agents.
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